Clemson and Georgia Tech are natural rivals that play every year in the new ACC alignment despite being in different divisions. The geographic proximity between the two schools was the main thinking in this set-up, but the closeness of the football games in recent years make it a rivalry that's growing bigger every year it seems. The rivalry's roots go back to when Tech was still not in the ACC and the events that led to the beginning of the Clemson tradition of $2 bills. Some of the biggest games in the early history of the rivalry were when John Heisman coached at Clemson and then left for Tech's larger financial offer.
The Tigers won the last two games at Bobby Dodd Stadium in Atlanta while the Yellow Jackets won the heartbreaker at Clemson last season. 12 of the last 15 games between the two schools have ended with a margin of 5 points or less between the winner and the loser.
Clemson will have to stop Calvin Johnson while not devoting so much attention to him that the Tech running attack is able to pile up yards with P.J. Daniels or through the rushing of quarterback Reggie Ball. The Tigers must get their running game on track with Reggie Merriweather and Kyle Browning. James Davis is not expected to play, although there are rumors to the contrary. Tech fans and news articles in the media in Atlanta seem to dwell upon the need to stop Chansi Stuckey for the Tigers but I'd think they may want to watch out for some of the other Clemson receivers as well. I'd put Curtis Baham as a bigger threat than Stuckey right now and the emergence of the freshmen receivers in recent weeks is something to look out for as well.
The only prediction I will make is that it might very well come down to the last possession of the game again based on the recent history of the series and the past two seasons for Clemson against all opponents.